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Preparative SFE/SFC System

JASCO is proud to announce the release of our new Preparative SFE/SFC system. This unit features a versatile modular design and excellent performance.

The heart of the system is JASCO’S patented award-winning back- pressure regulator which allows control of system pressure regardless of solvent composition and flowrate. The pumping system is based on the proven performance of our 1500 series analytical SFE/SFC system and can deliver up to 120ml/min of CO2 and 60 ml/min of modifier and flush solvents at pressures up to 35 MPa (5000 psi). Injections can be manual or fully automated. Repetitive injections can be performed to overlay chromatographic runs. Detection choices include UV and/or CD with MS interface capability.

Fraction collection of up to 8 fractions by time, signal level and/or slope is standard. In addition, spectral purity monitoring of Chiral molecules using the g-factor output of the CD detector is standard with the CD detector option.

Up to 20 mm x 250 mm columns can be accommodated in the column oven while 30mm and larger columns can be used outside the oven.

SF-Nav Process control software is designed for fully automated operation, monitoring and recording of chromatograms, temperatures, and pressures.

  • High Throughput
    The low viscosity and high diffusion coefficient of CO2 make it possible to perform separations and purifications with great efficiency in a short elution time.
  • Low cost
    Compared with a preparative HPLC, the total cost can be significantly reduced because of the use of inexpensive CO2 as mobile phase and the simplicity of sample recovery.
  • Safe and Environmentally friendly
    Nonflammable CO2 is safer than organic solvents. Using CO2 recovery can offer even less environmental burden.


1 Liquid CO2 Cylinder
2 Modifier
3 Liquid CO2 pump
4 Modifier pump
5 Heat Exchanger
6 Autosampler
7 Oven
8 Column
9 Detector
10 Rinse pump
11 Back pressure regulator
12 Switching valve
13 8-way valve
14 Gas-liquid separator
15 Collection bottles
16 Software for SFC

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